Sandwiched between the inner and outer lamellae are collections of osteons, or Haversian systems example. Within the bone, you can see the individual osteocytes within their lacunae and the small canaliculi through which the osteocytes extend processes to communicate with each other. The periosteum is relatively thin and consists primarily of an outer fibrous layer of dense irregular connective tissue.
Outside the periosteum are fibers of skeletal muscle associated with the extensor and flexor compartments of the leg. This tumor comprises atypical osteoblastic cells that have large hyperchromatic nuclei with nuclear pleomorphism and frequent mitoses, producing new bone matrix osteoid. The BEST diagnosis is:. Mutation and loss of function of the Rb and p53 genes are often encountered in this tumor.
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Both Rb and p53 are examples of:. She slipped on the stairs and suffered immediate severe pain in the knee. X-ray revealed a tumor which was a large area of decalcification with expansion of tibia, but with thinning of the cortex.
Tumors like this are usually treated by curetting. A case that was treated by partial resection of the bone is illustrated. This bone tumor:. Clinical History: This was a year-old white male who complained of pain and swelling in his hip. He gave a history of having been struck by a baseball four months previously.
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Other examples of small round cell tumor that might come into the differential diagnosis include the following EXCEPT :. This was followed by chemotherapy.
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He developed leukopenia, thrombocytopenia and a painful, linear, vesicular rash on his shoulder. Outside the periosteum are fibers of skeletal muscle associated with the extensor and flexor compartments of the. Clinical History: A year-old white farmer entered with a complaint of a lesion on the right cheek. It had been growing slowly for several years. Skin consists of keratinizing stratified squamous epithelium. The keratin layer is eosinophilic.
Nuclei are not present. Beneath the keratin layer is a layer of flat epithelial cells with small pyknotic nuclei.
Cells are regular and not crowded. These keratinocytes rest upon a layer of basal epithelium and a thin basement membrane. Beneath the epidermis is the dermis which consists of loose connective tissue. Within the dermis are sweat and sebaceous glands. Some slides contain hair follicles.
There is no inflammation.
The blood vessels are patent and do not contain thromboemboli. This skin tumor, which may arise from the basal layer of the epidermis or from dermal appendages is a:. Which one of the following histological features is typical of this tumor? Clinical history: A year-old man incurs extensive thermal burns to his skin and undergoes skin grafting procedures in the surgical intensive care unit. Two weeks later, he has increasing respiratory distress. Laboratory studies show hemoglobin of A chest radiograph shows extensive bilateral infiltrates with patchy areas of consolidation.
Image Gallery:. Based on these clinical findings, what is the likely causative agent? The organism was oxidase positive. What is the most likely organism? Clinical history: A suspicious envelope arrived for sorting at rural post office. The envelope was opened and found to contain white powder. Approximately two days later, the postal worker who handled the letter developed cutaneous boils, which were and 1 to 5 cm in diameter with central necrosis and eschars. He and his wife also developed a mild nonproductive cough with fatigue, myalgia for 72 hours, followed by severe dyspnea, diaphoresis and cyanosis.
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Temperature of Crackles were heard at the lung bases. A chest xray shows a widened mediastinum and small pleural effusions. Both died despite antibiotic therapy. Several cattle, horses, and sheep on the postal worker's farm also died. Subscribe Register Login. Your Name: optional. Your Email:. Colleague's Email:. Separate multiple e-mails with a ;. Send a copy to your email. Some error has occurred while processing your request. Please try after some time. Pathology Case Reviews. Add Item s to:. An Existing Folder. A New Folder. The item s has been successfully added to " ".
Thanks for registering! This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents published in that journal. The chart shows the evolution of the average number of times documents published in a journal in the past two, three and four years have been cited in the current year. Evolution of the total number of citations and journal's self-citations received by a journal's published documents during the three previous years.
Journal Self-citation is defined as the number of citation from a journal citing article to articles published by the same journal.
Evolution of the number of total citation per document and external citation per document i. International Collaboration accounts for the articles that have been produced by researchers from several countries. The chart shows the ratio of a journal's documents signed by researchers from more than one country; that is including more than one country address.
Not every article in a journal is considered primary research and therefore "citable", this chart shows the ratio of a journal's articles including substantial research research articles, conference papers and reviews in three year windows vs.