The field of precision medicine is relatively new, and extensive research is still warranted to enable useful implementation of this approach across different therapeutics specialties. Ray believes that ASCPT has been helpful in supporting the research by having dedicated issues that focus on precision medicine and pharmacogenomics in CPT. He also feels that inviting speakers at the Annual Meeting who are leaders in the field is evidence of ASCPT's support of precision medicine. He looks forward to seeing more scientific sessions on precision medicine research at the Annual Meeting.
He encourages them to attend the Annual Meeting and to make a point to attend the poster sessions and the networking sessions. Krina has had an atypical route to her pharmacometrics career.
A pharmacist by training, she received her BPharm degree from Saurashtra University in India in Her work in drug safety and medical writing helped her gain a deep understanding of drug development, clinical studies, and regulatory processes. As a medical writer, while working closely with clinical and pharmacology colleagues, she saw the impact of modeling and simulation in drug development and developed an interest in working in pharmacometrics.
She learned about a master's program that was being offered online designed for working professionals through the University of Maryland, Baltimore UMB , and she decided to pursue it.
She has also worked as a contractor with the Center for Translational Medicine at UMB, developed PBPK course modules for inclusion in master's programs, and conducted drug—drug interaction predictions for a Center for Translational Medicine client. She is glad to be working with expert pharmacometricians and clinical pharmacology scientists and is learning from them every day, while continuing to provide pharmacometrics services to clients to optimize clinical and preclinical studies to bring the best drugs forward for patients.
She admires his philosophy of effective communication of modeling and simulation results to make an impact on drug development decisions and tries to follow it in practice every day. Using modeling and simulation to effectively understand translation from nonclinical to human is of particular interest to Krina. She believes that translation from nonclinical in vitro and in vivo preclinical studies to human clinical results is not fully understood yet.
In general, modeling and simulation enables drug developers to make better decisions during each stage of drug development, which enables them to bring better drugs to the market faster. This is valuable to patients with diseases that have been difficult to treat, such as immune system—related diseases and rare genetic diseases. As Krina works remotely most of the time, ASCPT has helped her connect with the industry and stay in touch with what is the latest and greatest in the field.
She enjoys learning about different modeling approaches and their impact on regulatory and patient care decisions. Tanaya majored in pharmaceutical sciences and technology during her undergraduate studies at the Institute of Chemical Technology in Mumbai, India.
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This program played a pivotal role in firming her decision to pursue graduate studies in pharmaceutical sciences. Tanaya felt that the program was an extremely enriching experience that helped her lay a solid foundation in pursuing her goal of completing doctoral studies in the field. In , she joined the PhD program in pharmaceutics at the University of Florida, Center for Pharmacometrics and Systems Pharmacology, in Lake Nona, FL, where she has been working as a graduate research student under the guidance of Dr.
Sihem Bihorel. All of Tanaya's professors, starting in her undergraduate years, have had an impact on her. Robert Straubinger and Bihorel, for providing her with opportunities to work on exciting research projects and for their excellent mentorship, which allow her to hone her research skills in the field. Tanaya's PhD research projects primarily focus on the application of QSP models to address issues in the areas of oncology and cardiotoxicity.
The process of systematically investigating the mechanisms of efficacy and toxicity of chemotherapeutics through the use of mathematical modeling is something that deeply interests her. Tanaya hopes to play an important role as a researcher in this area to better integrate this valuable tool with the process of drug development to improve patient treatment. The areas of QSP and pharmacometrics have been rapidly gaining momentum, as they contribute immensely to assessing the safety and efficacy of investigational new drugs. As valuable quantitative tools, they can help in designing optimal doses and dosing regimens to improve treatment outcomes in patients.
She decided to join the Society for the opportunity to connect with scientists and professionals from multiple disciplines, whose common goal is to advance patient care through the science and practice of clinical pharmacology and therapeutics.
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Being one of the largest organizations in the field, ASCPT serves as a platform for both professional and personal development of young scientists who aspire to revolutionize health care by applying interdisciplinary knowledge and research better ways to understand and improve treatment outcomes in patients. Her membership in ASCPT has allowed Tanaya to interact with scientists and professionals from several different fields, thus allowing her to gain valuable insights and information, for the advancement of her career.
She is grateful to the Society for the opportunities to showcase her work as a Presidential Trainee at the Annual Meeting. This experience allowed her to gain valuable feedback from other professionals on her work, resulting in visibility and recognition of her work and development of her career. Quantitative pharmacology, which uses models to describe the fate of drugs in the body and the association to safety and efficacy, is not currently included in the curriculum in the undergraduate programs, but it can be selected as an elective undergraduate course at select universities in Sweden.
Uppsala University has just started the first master's program in pharmaceutical modeling in Sweden, in which pharmacometrics is one of the disciplines. Uppsala University also hosts the largest academic pharmacometrics research group in Sweden. Simonsson is associated with this research group.
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At the moment, there is only one big pharmaceutical company in Sweden researching and developing drugs, AstraZeneca. Sweden hosts a large number of biotechnology companies in which translational medicine is important. In Sweden, clinical pharmacists are not routinely involved in assisting with dose selection in the clinics.
Simonsson hopes that in the future this will change. She encourages Swedish physicians and pharmacists to cooperate more in the field of therapeutic drug monitoring. She hopes that Sweden will be inspired by how other neighboring countries like The Netherlands do this. Simonsson earned both her Masters of Science in Pharmaceutical Sciences and her pharmacist degree at Uppsala University.
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