Silica Nanoparticles as Drug Delivery System for Immunomodulator GMDP

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View Cart. Publisher: ASME. Publish Date: Language: English - US. ISBN: Share or Print. Early Bird Sale. Book Options Format. Print Book. The stages of pyrolysis of aglycone, peptide fragment and carbohydrate residue of thiophenylglycoside of muramyl dipeptide in the pristine state and adsorbed on the silica surface have been determined. LRA is a Ph.

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TVK is a Ph. VNT is a Ph. AEZ is a Dr. VYC is Dr. This article is published under license to BioMed Central Ltd. Skip to main content Skip to sections. Advertisement Hide. Download PDF. Nanoscale Research Letters December , Cite as.

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Open Access. First Online: 13 May Background It has long been known that non-specific stimulation of the immune system can be brought about by exposure to bacteria or components extracted from bacterial cells [ 1 ]. Open image in new window. Loss of aglycone and carbohydrate moiety occurs during the first and the second stages of pyrolysis. But it is observed that there are different ratios of peak intensities on the TPD-curve for molecular and fragment ions of corresponding products.

Thus, the first stage proceeds via preferential removal of benzyl alcohol, while the second stage-by elimination of thiophenol. The intensity of a thiophenol molecular ion peak is high as the thiophenol molecular ion is stable. However, the sequence of their stages and temperature range are changing. So, amide I and amide II bands are not obscured by overlapping with absorption bands of physically adsorbed molecular water.

This testifies that the binding to the silica surface occurs due to peptide fragment resulting in the change of its conformation under adsorption. Pr, pristine state; Ad, adsorbed on the silica surface. Table 3 Assignments of amide bands to the secondary structure of peptides and proteins literature data. J Biol Chem , — R CrossRef Google Scholar. Infect Immun , — Google Scholar. Biochem Biophys Res Comm , — Pythagora: Roma; Dzierzbicka K, Wardowska A, Trzonkowski P: Recent developments in the synthesis and biological activity of muramylpeptides.

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Silica Nanoparticles as Drug Delivery System for Immunomodulator GMDP - ASME

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